| Autor(en) |
Titel |
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| Cantu MA, Lupo PJ, Bilgi M, Hicks MJ, Allen CE, McClain KL |
Optimal therapy for adults with Langerhans cell histiocytosis bone lesions. |
PloS one 2012, 7:e43257 |
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| There is little data on treatment of Langerhans cell histiocytosis (LCH) in adults. Available data is on small numbers of patients with short follow-up times and no comparison of results from different treatment regimens. We analyzed the responses of adult LCH patients with bone lesions to three primary chemotherapy treatments to define the optimal one. |
| Canuet M, Kessler R, Jeung MY, Métivier AC, Chaouat A, Weitzenblum E |
Correlation between high-resolution computed tomography findings and lung function in pulmonary Langerhans cell histiocytosis. |
Respiration; international review of thoracic diseases 2007, 74: 640 |
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| Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon interstitial lung disease which can lead to serious respiratory failure. The correlation between high-resolution computed tomography (HRCT) findings and lung function have not been studied in depth. |
| Caputo, R |
Text Atlas of Histiocytic Syndromes : A Dermatological Perspective. |
Informa Healthcare 1998 |
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| Cassady JR |
Current role of radiation therapy in the management of histiocytosis-X. |
Hematology/oncology clinics of North America 1987, 1: 123 |
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| With increasing utilization of systemic agents such as prednisone, oral alkylating agents and the vinca alkyloids, the use of radiation has decreased. In this article, current indications for radiation therapy are presented and recommended techniques and dose fractionation discussed. |
| Chikwava K, Jaffe R |
Langerin (CD207) staining in normal pediatric tissues, reactive lymph nodes, and childhood histiocytic disorders. |
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2004 Nov-Dec; 7: 607 |
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| Langerin is a recently identified lectin for which antibodies can be used as immunohistochemical markers of Langerhans cells (LCs). We describe the distribution of staining in autopsy pediatric tissues, dermatopathic and other reactive lymph nodes, and childhood histiocytic lesions using the 12D6 antibody (Novocastra). We also correlate CD1a (antibody O1O) staining to these factors. Langerin on epidermal LCs has a coarsely granular cell membrane and a cytoplasmic staining pattern that is always associated with CD1a expression. All 6 skin samples had Langerin(+)/CD1a(+) LCs within the epidermis. Six of 8 thymuses showed single scattered dendritic-shaped cells in the medulla and rare cells within Hassall corpuscles that coexpressed Langerin and CD1a. Cortical thymocytes were CD1a(+)/Langerin(-). Four of 8 livers examined showed a sinusoidal lining pattern of Langerin+/CD1a(-). All 15 autopsy lymph nodes showed a similarly strong Langerin(+)/CD1a(-) sinus pattern of staining on fixed tissue elements, mostly in medullary sinuses. All 12 dermatopathic lymph nodes showed accumulation of Langerin(+)/CD1a(+) cells in the pale paracortical nodules. All 24 instances of LC histiocytosis (LCH) were Langerin(+)/CD1a(+). All 12 non-LCH histiocytic disorders are negative for Langerin in the histiocytes of interest. We conclude that Langerin is coexpressed with CD1a on LCs and LCH. Lymph node sinuses and hepatic sinusoids show Langerin(+)/CD1a(-) cells, indicating that, when used alone to confirm LCH infiltration, the 12D6 antibody should be used with caution. At other sites, its diagnostic accuracy is similar to that of CD1a. |
| Chohan G, Barnett Y, Gibson J, Reddel SW, Barnett MH |
Langerhans cell histiocytosis with refractory central nervous system involvement responsive to infliximab. |
Journal of neurology, neurosurgery, and psychiatry 2012, 83: 573 |
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| Chu A |
Dermatological Aspects and Presentation of an Adult Clinic . |
Oral Presentation at the Annual Meeting of the Histiocyte Society Vienna 2011 |
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| Colombat M, Stern M, Groussard O, Droz D, Brauner M, Valeyre D, Mal H, Taillé C, Monnet I, Fournier M, Herson S, Danel C |
Pulmonary cystic disorder related to light chain deposition disease. |
American journal of respiratory and critical care medicine 2006 Apr 1; 173: 777 |
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| Light chain deposition disease (LCDD) is a rare disorder that very uncommonly affects the lung. We report three cases of severe cystic pulmonary LCDD leading to lung transplantation. Such a presentation has never been previously reported. The three patients present with a progressive obstructive pulmonary pattern associated with numerous cysts diffusely distributed in both lungs. The disease was histologically characterized by non-amyloid amorphous deposits in the alveolar walls, the small airways and the vessels. It was associated with emphysematous-like changes and small airway dilation. Monotypic kappa light chain fixation was demonstrated on the abnormal deposits and along the basement membranes. Electron microscopy revealed coarsely granular electron-dense deposits in the same localizations. Mild extrapulmonary deposits were found in salivary glands in one patient. No immunoproliferative disorder was identified. We conclude that LCDD may primarily affect the lung, present as a pulmonary cystic disorder, and lead to severe respiratory insufficiency. |
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